Galleria mellonella larvae as models for studying fungal virulence
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چکیده
منابع مشابه
The Galleria mellonella larvae as an in vivo model for evaluation of Shigella virulence
Shigella spp. causing bacterial diarrhea and dysentery are human enteroinvasive bacterial pathogens that are orally transmitted through contaminated food and water and cause bacillary dysentery. Although natural Shigella infections are restricted to humans and primates, several smaller animal models are used to analyze individual steps in pathogenesis. No animal model fully duplicates the human...
متن کاملDeveloping the potential of using Galleria mellonella larvae as models for studying brain infection by Listeria monocytogenes
The use of mammals for studying microbial pathogens or for assessing the efficacy of a variety of pharmaceutical agents has contributed enormously to our knowledge of microbial virulence and in the development of novel therapeutic strategies. However, despite these advances, there is a recognition that the number of mammals used in such tests must be reduced to the minimum and that alternative,...
متن کاملProlonged pre-incubation increases the susceptibility of Galleria mellonella larvae to bacterial and fungal infection.
Galleria mellonella larvae are widely used for assessing the virulence of microbial pathogens and for measuring the in vivo activity of antimicrobial agents and produce results comparable to those that can be obtained using mammals. The aim of the work described here was to ascertain the effect of pre-incubation at 15°C for 1, 3, 6 or 10 weeks on the susceptibility of larvae to infection with C...
متن کاملAssessment of Listeria monocytogenes virulence in the Galleria mellonella insect larvae model
Several animal models have been used to understand the molecular basis of the pathogenicity, infectious dose and strain to strain variation of Listeria monocytogenes. The greater wax worm Galleria mellonella, as an alternative model, provides some useful advantages not available with other models and has already been described as suitable for the virulence assessment of various pathogens includ...
متن کاملSome effects of x-irradiation on larvae of Galleria mellonella.
During the summer of 1965, the fungus Spicaria rileyi was frequently associated with dead Pseudoplusia includens larvae on various crops in southeastern Alabama. Since this insect, sometimes referred to as the false looper, has become of increasing economic importance in Alabama (Canerday, J. Econ. Entomol., in press, 1966), the pathogenicity and potential control value of S. rileyi for P. k&de...
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ژورنال
عنوان ژورنال: Fungal Biology Reviews
سال: 2010
ISSN: 1749-4613
DOI: 10.1016/j.fbr.2010.04.001